![]() ![]() The complexes obtained showed no activity (IC 50 > 50 µM) in comparison with structurally related Cu(II) complex exhibiting dose-dependent toxicity comparable to that of cisplatin (IC 50 = 3.06 ± 0.07 µM (Cu(II) complex), IC 50 = 9.2 ± 0.5 µM (cisplatin)). All complexes have been screened in vitro for their cytotoxic activity against Hep2 cancer cell line. Cl non-covalent interactions which can be regarded as halogen bonding.In the structure of 4, mononuclear units have been found to form infinite zigzag chains due to the presence of Cl Crystal structures of mononuclear complexes 1, 4 and 5 have been determined by single-crystal X-ray diffraction. Mass spectrometry and UV–Vis spectroscopy have been used to show the behavior of complexes in ethanol solution and phosphate buffer saline. ![]() All complexes have been characterized by physicochemical and spectroscopic methods. L♲H 2O ( 5), where L-4,5-dichloro-isothiazole-3-carboxylate anion and phen-1,10-phenanthroline are reported.In this study, Ni(II) and Co(II) complexes ( 1), ( 2), ( 3), ♲H 2O♾tOH ( 4♲H 2 O), and ![]()
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